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nencki.gov.pl » Working Groups » Others »
Laboratory of Preclinical Studies in Neurodegenerative Diseases

  Head
Grażyna NIEWIADOMSKA

Staff
Anna GĄSIOROWSKA, Anna MIETELSKA (PhD Student), Marcin MAZURKIEWICZ (PhD Student), Teresa CYMBALAK (technician)

 

Research profile

Neurodegeneration is a common theme of many nervous system diseases, such as Alzheimer's disease, Parkinson's disease, ALS, head trauma, epilepsy and stroke. These disorders are devastating and expensive, with annual costs currently exceeding several hundred billion dollars in the United States alone, and current treatments are inadequate. Adding to the urgency of the problem is the fact that the incidence of these age-related disorders is increasing rapidly as population demographics change.

Our studies concentrate on the degeneration processes in ageing neurons and in the reversal of brain dysfunction induced by ageing. The research group establishes the link between cellular neural processes and the behavioural expression of the brain processes during physiological and pathological ageing. Our main research interest are the neurochemical and morphological correlates of the basal forebrain cholinergic system in the adult and ageing brain with a special attention to the protective effects of neurotrophic factors as potential therapeutic agents during ageing or in the neurodegenerative diseases. Towards this end, the team has tried to implement treatment protocols and conduct longitudinal studies that can be used in Alzheimer’s research. The work uses both rats and mice and has currently centred on tau protein involvement in cytoskeletal signalling in animal models of neurodegenerative disorders.

Current research activities

  • cytoskeletal transport in the aging brain: focus on the cholinergic system

  • the septo-hippocampal system, learning and recovery of function

  • development of an animal model for tauopathies using aged rats

  • development of novel treatments for neurodegenerative diseases: testing in animal models and assessment of drug safety and pharmacology

Selected publications

Niewiadomska G. Baksalerska-Pazera M. and Riedel G. The septo-hippocampal system, learning and recovery offunction. Progress Neuro-Psychopharm. Biol. Psych. 2007 (in press).

Niewiadomska, G., Baksalerska-Pazera, M., Gasiorowska, A. and Mietelska, A. NGF differentially affects spatial and recognition memory in aged rats. Neurochemical Research, 31(12):1481-1490, 2006.

Niewiadomska G., Baksalerska-Pazera M, Lenarcik l, and Riedel G. Compartmental protein expression ofTau, GSK-3~ and TrkA in cholinergic neurons of aged rats. J Neural Trans 113 (11):1733-1746, 2006.

 

Niewiadomska G., Baksalerska-Pazera M. and Riedel G. Cytoskeletal transport in the aging brain: focus on the cholinergic system. Reviews in the Neurosciences, 17(6):581-618, 2006.

Niewiadomska, G., Baksalerska-Pazera, M. and Riedel, G. Altered cellular distribution of phospho- Tau protein s coincides with impaired retro grad e axonal transport of NGF in aged rats. Ann. N.Y. Acad. Sci. Vol. 1048:287-295, 2005.

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Published at: 2007-03-01 20:29
 

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