Anna GĄSIOROWSKA, Anna MIETELSKA
Marcin MAZURKIEWICZ (PhD
Neurodegeneration is a common theme of many nervous system diseases, such as
Alzheimer's disease, Parkinson's disease, ALS, head trauma, epilepsy and stroke.
These disorders are devastating and expensive, with annual costs currently
exceeding several hundred billion dollars in the United States alone, and
current treatments are inadequate. Adding to the urgency of the problem is the
fact that the incidence of these age-related disorders is increasing rapidly as
population demographics change.
concentrate on the degeneration processes in ageing neurons and in the reversal
of brain dysfunction induced by ageing. The research group establishes the link
between cellular neural processes and the behavioural expression of the brain
processes during physiological and pathological ageing. Our main research
interest are the neurochemical and morphological correlates of the basal
forebrain cholinergic system in the adult and ageing brain with a special
attention to the protective effects of neurotrophic factors as potential
therapeutic agents during ageing or in the neurodegenerative diseases. Towards
this end, the team has tried to implement treatment protocols and conduct
longitudinal studies that can be used in Alzheimer’s research. The work uses
both rats and mice and has currently centred on tau protein involvement in
cytoskeletal signalling in animal models of neurodegenerative disorders.
cytoskeletal transport in the aging brain: focus on the cholinergic system
the septo-hippocampal system, learning and
recovery of function
development of an animal model for
tauopathies using aged rats
development of novel treatments for neurodegenerative diseases: testing in
animal models and assessment of drug safety and pharmacology
Niewiadomska G. Baksalerska-Pazera M. and Riedel G. The septo-hippocampal
system, learning and recovery offunction. Progress Neuro-Psychopharm. Biol.
Psych. 2007 (in press).
Niewiadomska, G., Baksalerska-Pazera, M., Gasiorowska, A. and Mietelska, A. NGF
differentially affects spatial and recognition memory in aged rats.
Neurochemical Research, 31(12):1481-1490, 2006.
Niewiadomska G., Baksalerska-Pazera M, Lenarcik l,and Riedel G.
Compartmental protein expression ofTau, GSK-3~ and TrkA in cholinergic neurons
of aged rats. J Neural Trans 113 (11):1733-1746, 2006.
Niewiadomska G., Baksalerska-Pazera M. and Riedel G. Cytoskeletal transport in
the aging brain: focus on the cholinergic system. Reviews in the Neurosciences,
Niewiadomska, G., Baksalerska-Pazera, M. and Riedel, G. Altered cellular
distribution of phospho- Tau protein s coincides with impaired retro grad e
axonal transport of NGF in aged rats. Ann. N.Y. Acad. Sci. Vol. 1048:287-295,