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Department of Neurophysiology
Laboratory of Defensive Conditioned Reflexes
Laboratory of Ethology
Laboratory of Limbic System
Laboratory of Molecular and Systemic Neuromorphology
Interinstitute Laboratory of Neuromuscular Plasticity
Laboratory of Neuropsychology
Laboratory of Psychophysiology
Laboratory of Reinnervation Processes
Laboratory of Visual System
Laboratory of Preclinical Studies in Neurodegenerative Diseases
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nencki.gov.pl » Working Groups » Department of Neurophysiology »
Laboratory of Molecular and Systemic Neuromorphology


Monika MALINOWSKA, Adam GORLEWICZ (PhD student), Maciej GAWLAK (technician), Filip KONOPACKI (PhD student, Nencki Institute), Ewa WILCZEK (PhD student, Medical University of Warsaw), Agnieszka WALCZAK (undergraduate student, Warsaw Agricultural University)

Research profile

Our research interest focuses on the structural and functional plasticity of the nervous system in both health and disease. We study phenomena occurring at various levels of organization, including (i) anatomical sub-structures of the brain, (ii) the nervous tissue with all its cellular constituents, (iii) subcellular-, and (iv) macromolecular levels. One major issue that we investigate is the role of extracellular proteolysis in synaptic plasticity in the brain, and at the neuromuscular junctions; this involves also the studies of pathological plasticity occurring in various forms of epilepsy. Another major project focuses on the role of immediate-early gene expression in learning and behaviour. We are also interested in glial cell biology, as well as in advances in microscopy and tissue-visualization techniques. We cooperate extensively with several groups in the Nencki and at the Medical University in the fields of neurobiology and cancer.

Methods: Immunocytochemistry and in situ hybridization at the level of confocal- and electron-microscopy. High resolution in situ zymography. Neuroanatomical methods. Molecular biology techniques.

Current research activities

  • Studies on synaptic localization and function of matrix metalloproteinase-9 (MMP-9) in the rat hippocampus.
  • Studies on the function of MMP-9 in astrocytes.
  • Investigation of the possible pathogenic role of MMP-9 in temporal lobe epilepsy
  • Studies on the expression, localization, and role of matrix metalloproteinases in the neuromuscular junction.
  • Studies on the neuroanatomical correlates of different forms of learning and memory in the rat

Selected publications

Wilczynski GM, Konopacki FA, Wilczek E, Lasiecka Z, Gorlewicz A, Michaluk P, Wawrzyniak M, Malinowska M, Olkuski P, Kolodziej LR, Konopka W, Duniec K, Mioduszewska B, Nikolaev E, Walczak A, Owczarek D, Gorecki DC, Zuschratter W, Ottersen OP, and Kaczmarek L. Important role of matrix metalloproteinase 9 (MMP-9) in epileptogenesis. J Cell Biol 180: 1021-1035, 2008.

The possible role of factor H in colon cancer resistance to complement attack. Wilczek E, Rzepko R, Nowis D, Legat M, Golab J, Glab M, Gorlewicz A, Konopacki F, Mazurkiewicz M, Sladowski D, Gornicka B, Wasiutynski A Wilczynski GM Int. J. Cancer 2008; 122: 2030-2037

Konopacki FA, Rylski M, Wilczek E, Amborska R, Detka D, Kaczmarek L, Wilczynski GM. Synaptic localization of seizure-induced matrix metalloproteinase-9 mRNA. Neuroscience. 2007;150: 31-39.

Michaluk P, Kolodziej L, Mioduszewska B, Wilczynski GM, Dzwonek J, Jaworski J,Gorecki DC, Ottersen OP, Kaczmarek L. Beta-dystroglycan as a target for MMP-9, in response to enhanced neuronalactivity. J Biol Chem. 2007; 282: 16036-16041

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Published at: 2008-04-24 14:44

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