Paweł BOGUSZEWSKI, Mark
J. HUNT, Ksenia MEYZA (PhD Student), Karolina NOWAK (PhD Student), Jolanta ZAGRODZKA,
Monika FALIŃSKA (technician), Maciej OLSZEWSKI (technician)
Neurophysiological and neurochemical mechanisms of a) emotional behavior (with special attention paid to aggression, fear, anxiety and social behavior) and b) schizophrenia are investigated using a variety of techniques (electrophysiology, classical conditioning and spontaneous behavior) in awake rats. We study the fundamental brain regions which have been implicated in these phenomena, primarily by analyzing their electrophysiological activity.
Current research activities
ethopharmacological studies on the emotional behavior of rats;
studies of the electrophysiological activity and c-fos gene expression, evoked by novel environmental stimuli in limbic structures using genetically selected rats of different emotional reactivity (Swiss sublines RHA/verh and RLA/verh);
changes in emotion related to aging in rats;
electrophysiological studies on the activity (local field potentials) of various limbic structures (mainly amygdala and hippocampus) in awake rats with chronically implanted electrodes. The rats are tested in two paradigms:
classical (Pavlovian) fear conditioning, which enables the study of fear and extinction
freely moving animals in various behavioral situations (open field, plus maze etc.);
electrophysiological, pharmacological and behavioral studies using the NMDA receptor model of schizophrenia in rats. Electrophysiological activity (local field potential) is recorded from various limbic structures, such as the nucleus accumbens, prefrontal cortex, hippocampus and amygdala.
Meyza KZ, Boguszewski PM, Nikolaev E, Zagrodzka J. The effect of age on the dynamics and the level of c-Fos activation in response to acute restraint in Lewis rats. Behav Brain Res. 18;180(2):183-9. (2007).
Knapska E, Nikolaev E, Boguszewski P, Walasek G, Blaszczyk J, Kaczmarek L, Werka T.; Between-subject transfer of emotional information evokes specific pattern of amygdala activation. Proc. Natl. Acad. Sci. USA, 103(10):3858-62. Epub 2006 Feb 23. (2006)
Jelen P., Soltysik S., Zagrodzka J. 22-kHz ultrasonic vocalization as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state. Behav. Brain Research 141(1):63-72 (2003).
Korzeniewska A., Mańczak M., Kamiński M., Blinowska K.J., Kasicki S. Determination of information flow direction among brain structures by a modified Directed Transfer Function (dDTF) method. J. Neurosci. Methods 125(1-2):195-207 (2003).
Sławińska U., Kasicki S.; Altered EMG activity pattern of rat soleus muscle transposed into the bed of antagonist muscle. J. Neurosci. 22(14): 5808-5812 (2002).