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Department of Molecular and Cellular Neurobiology
Laboratory of Bioinformatics and Systems Biology
Laboratory of Calcium Binding Proteins
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Laboratory for Mechanisms of Transport Through Biomembranes
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nencki.gov.pl » Working Groups » Department of Molecular and Cellular Neurobiology »
Laboratory of Bioinformatics and Systems Biology

Head
Krzysztof PAWŁOWSKI

Staff
Anna LENART (PhD student), Teresa SZCZEPIŃSKA (PhD student)

Research profile

Structure and function predictions for proteins important in human disease, in particular uncharacterised transmembrane proteins; Systems biology analysis of gene expression data; Evolutionary analysis of gene expression profiles.

Current research activities

  • Structure / function analysis and evolutionary history of CLCAs, a novel enzyme family;
  • Structure / function analysis of a novel family of putative transmembrane receptors;
  • Studying expression profiles of drug targets;
  • New methods for pathway analysis of gene expression data: development of the GSEA method (gene set enrichment analysis)

Selected publications

Pierrou S, Broberg P, O'donnell R, Pawlowski K, Virtala R, Lindqvist E, Richter A, Wilson S, Angco G, Moller S, Bergstrand H, Koopmann W, Wieslander E, Stromstedt PE, Holgate S, Davies D, Lund J, Djukanovic R. (2006) Expression of Genes Involved in Oxidative Stress Responses in Airway Epithelial Cells of COPD Smokers. Am J Respir Crit Care Med. Epub ahead of print

Pawlowski K, Lepisto M, Meinander N, Sivars U, Varga M, Wieslander E. (2006) Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels. Proteins. 63(3):424-39

Stenner-Liewen F, Liewen H, Zapata JM, Pawlowski K, Godzik A, Reed JC. (2002) CADD, a Chlamydia protein that interacts with death receptors. J Biol Chem. 277(12):9633-6

Pawlowski K, Godzik A. (2001) Surface map comparison: studying function diversity of homologous proteins. J Mol Biol. 309(3):793-806

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. (2001) PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 26(2):85-7



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Published at: 2007-03-09 21:40
 

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