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nencki.gov.pl » Working Groups » Department of Molecular and Cellular Neurobiology »
Laboratory of Neuroplasticity

Head
Małgorzata KOSSUT

Staff
Kalina BURNAT, Ewa SIUCINSKA, Anna SKIBINSKA, Joanna URBAN-CIECKO, Jan JABLONKA (PhD student), Aleksandra RADWANSKA (PhD student), Renata ZAKRZEWSKA (Technician)

Research profile

Cellular, molecular, and systemic mechanisms of neuroplasticity. Our investigations explore a)  learning-induced plasticity of brain cortex of rodents, b) reorganization  of cerebral cortex after stroke and during ageing, c) developmental plasticity of cat visual system.
The role of inhibition in learning –dependent plasticity is of special interest.  We found upregulation of inhibitory interactions and GABA-ergic markers in the cortex remodelled by the learning experience. We monitor changes in GABA synthesis, GABAergic neurons and synapses, GABA transportres and receptors. IR labeling of calcium binding proteins and immediate early genes allows us to identify the neuronal circuits involved in learning. We conduct extra- and intracellular electrophysiological recordings characterizing learning-dependent changes in neuronal responses.
In a separate project we investigate plasticity of the injured brain. We described spontaneous remodelling of brain cortex after stroke and demonstrated impairment of neuroplasticity in the peri-stroke region .We investigated the influence of inflammatory reaction, spreading depression and interhemispheric interaction of perilesional plasticity In a clinical brain imaging study we investigate recovery from unilateral neglect
In the visual development project we found that visual deprivation impairs global motion perception. We investigate the post-deprivation anatomical changes in retina and other visual structures

Current research activities

  • GABA-ergic system. Visualization of inhibitory and excitatory synapses modified by learning. Immunolabeling of GABA transporters and CCK and somatostatin containing  neurons in the cortex reorganized by learning.
  • Mapping the brain during learning. Visualization of the global pattern of brain activation at different stages of the learning process. Identifications of neurons involved in learning by in situ hybridization of arc and immunolabeling of  proteins of other early response genes.
  • Electrophysiological correlates of learning. Whole cell patch registrations from neurons in brain slices of mice with GPF/c-fos trangen after behavioral  Investigations of tonic and phasic regulation in cortical neurons.
  • Brain plasticity after stroke – visualization of spontaneous and induced neuroplasticity in sensory cortical representation by 2-deoxyglucose autoradiography. FMRI brain imaging in  stroke patients with unilateral neglect  undergoing different strategies of neurorehabilitation.
  • Development of visual system. Visual deprivation of kittens, behavioral training, SMI32 immunolabeling.

Selected publications

Jablonka JA, Witte OW, Kossut M. 2007.  Photothrombotic infarct impairs experience-dependent plasticity in neighboring cortex. Neuroreport. 18(2):165-9.

Kozlowska, H., Jablonka,J., Janowski, J., Jurga, M., Kossut, M., Domonska-Janik, K. 2007. Abortive transplantation of human cord blood-derived neurol-like stem cells in rat model of cortical infarct. Stem Cells and Development. 16(3):481-8.

Tokarski K., Urban-Ciecko J., Kossut M., Hess G. 2007. Sensory learning-induced enhancement of inhibitory transmission in mice barrel cortex. Eur. J. Neurosci.26:134-141.

Siucińska E., Kossut M. (2006) Short-term sensory learning does not alter parvalbumin neurons in the barrel cortex of adult mice a double labeling study. Neurosci. 138: 715-724.

Cybulska-Kłosowicz A., Kossut M. (2006) Early-phase of learning enhances communication between brain hemispheres. Eur. J. Neurosci. 24: 1470-1476.

Burnat K., Stiers P., Arckens L., Vandenbusche E., Żernicki B. (2005) Global form perception in cats early deprived of pattern vision. Neuroreport 16: 751-754.



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Published at: 2007-11-19 11:15
 

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