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nencki.gov.pl » Working Groups » Department of Molecular and Cellular Neurobiology »
Laboratory of Molecular Neurobiology

   Head
Leszek KACZMAREK

Staff
Magdalena DZIEMBOWSKA (PhD), Robert FILIPKOWSKI (PhD), Evgeni NIKOLAEV (PhD), Marcin RYLSKI (PhD), Agata KLEJMAN (PhD), Victoria LIOUDYNO (PhD), Katarzyna BIEGAŃSKA (PhD student), Ludwika GAWRYŚ (PhD student), Tomasz GÓRKIEWICZ (PhD student), Filip KONOPACKI (PhD student), Anna KIRYK (PhD student),  Piotr MICHALUK (PhD student), Renata SAGANEK (PhD student), Marcin WAWRZYNIAK (PhD student), Dorota OWCZAREK (Technician), Krystyna TABEŃSKA (Technician), Grażyna WOŹNIAK (Technician)

Research profile

The long-term goal of our work is to understand molecular bases of persistent neuronal responses. Two sets of phenomena are under investigation: neural plasticity, including learning and memory formation, and neurodegeneration bearing features of apoptosis. Both sets of conditions share similarities in involving excitatory amino acids acting on specific receptors. Furthermore, as a result of neuronal stimulation, transduction of a signal into cell nucleus leads to activation to at least partially overlapping sets of transcription factors, and their target genes. Thus, it appears that it is not possible to understand one of these processes separately of the other. More information about Laboratory on the web page

Current research activities

Matrix metalloproteinases (especially MMP-9) and their inhibitors (e.g., TIMP-1) in neuronal plasticity and cell death: regulation of gene expression, subcellular localization and function (physiology and behavior)

Cyclin D2 in adult brain neurogenesis; the role of adult brain neurogenesis in neuronal plasticity, learning and memory, depression and addiction

ICER, the endogenous CREB antagonist in neuronal apoptosis and plasticity

Novelty response involving immediate early gene expression in the adult auditory cortex

Selected publications

Wilczynski G.M., Konopacki F.A., Wilczek E., Lasiecka Z., Gorlewicz A., Michaluk P., Wawrzyniak M., Malinowska M., Okulski P., Kolodziej L.R., Konopka W., Duniec K., Mioduszewska B., Nikolaev E., Walczak A., Owczarek D., Gorecki D.C., Zuschratter W., Ottersen O.P., Kaczmarek L. Important role of matrix metalloproteinase 9 (MMP-9) in epileptogenesis. J. Cell Biol., 180: 1021-1035, 2008.

Michaluk P., Kolodziej L., Mioduszewska B., Wilczynski G.M., Dzwonek J., Jaworski J., Gorecki D.C., Ottersen O.P., Kaczmarek L., b-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity. J. Biol. Chem., 282:16036-16041, 2007.

Knapska E., Radwanska K., Werka T., Kaczmarek L., Functional internal complexity of amygdala: focus on gene activity mapping following behavioral training and drugs of abuse. Physiol. Rev., 87: 1113-1173, 2007.

Knapska E., Nikolaev E., Boguszewski P., Walasek G., Blaszczyk J., Kaczmarek L., Werka T. Between-subject transfer of emotional information evokes specific pattern of amygdala activation. Proc. Natl. Acad. Sci. USA, 103: 3858-3862, 2006.

Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R.M., Silva, A.J., Kaczmarek, L., Huntley, G.W. Matrix metalloproteinase (MMP-9) is required for hippocampal late-phase LTP and memory. J. Neurosci., 26: 1923-1934, 2006.

Kowalczyk A., Filipkowski RK, Rylski M., Wilczynski G.M., Konopacki F.A., Jaworski J., Ciemerych M.A., Sicinski P., Kaczmarek L. The critical role of cyclin D2 in adult neurogenesis. J. Cell Biol., 167: 209-213, 2004.

Frankland P.W., Bontempi B., Talton L.E., Kaczmarek L., Silva A.J. The involvement of the anterior cingulate cortex in remote contextual fear memory. Science, 304: 881-883, 2004.

Jaworski J., Mioduszewska B., Sanchez-Capelo A.,  Figiel I.,  Habas A. Gozdz A., Proszynski T. Hetman M., Mallet J.,  Kaczmarek L. Inducible cAMP Early Repressor, an endogenous antagonist of cAMP Responsive Element-Binding Protein, evokes neuronal apoptosis in vitro.  J. Neurosci, 23: 4519-4526, 2003.



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Published at: 2008-05-26 15:29
 

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