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nencki.gov.pl » Working Groups » Department of Molecular and Cellular Neurobiology »
Laboratory of Molecular Basis of Brain Plasticity

Head
Jolanta SKANGIEL-KRAMSKA

Staff
Artur CZUPRYN, Dorota NOWICKA, Karolina ROGOZIŃSKA (PhD student), Magdalena KARETKO (PhD student), Monika ALEKSY (technician)

Research profile

The laboratory focuses on studying neuronal plasticity during postnatal development and in the adult brain. The barrel cortex of rodents is used as a model system and plastic changes are induced by learning, sensory deprivation and stimulation. Another topic is concentrated on neuronal plasticity occuring after cerebral stroke in the adult brain, and focal photothrombotic cortical stroke serves as an experimental model. For this purpose following methods are used: quantitative receptor binding autoradiography, immunocytochemistry, histochemistry for synaptic zinc, in situ synaptic zinc chelation, in situ zymography hybridization in situ , Western blotting.

Current research activities

  • neuroreceptors. Investigations of effects of sensory deprivation and cortical stroke on the distribution and level of different neurotransmitter receptors in the primary somatosensory cortex of rodents. Alterations of neuroreceptor binding in different areas of rat brain after phototrombotic cortical stroke;
  • synaptic zinc. Studies on the role of synaptic zinc in process of sensory learning. The effects of zinc chelation on plastic changes induced in the barrel cortex;
  • synaptic proteins. Immunochemical studies on the expression of various presynaptic and postsynaptic proteins during postnatal development and after induction of plastic changes in the barrel cortex. Studies on the effects of CNS damage (cortical photothrombotic stroke, transaction of the spinal cord) on the expression of markers of axonal sprouting;
  • perineuronal nets. Investigations of involvement of extracellular matrix components in cortical plasticity especially after recovery from cortical stroke.

Selected publications

Liguz-Lecznar M.,Skangiel-Kramska J.(2007)Vesicular glutamate transporters VGLUT1 and VGLUT2 in the developing mouse barrel cortex. Int. J. Devl Neurosci.25,107-114.

Szewczyk B., Sowa M., Czupryn A., Wierońska J.M., Brański P., Sadlik K., Opoka W., Piekoszewski W., Śmiałowska M., Skangiel-Kramska J., Pilc A., Nowak G. (2006) Increase in synaptic hippocampal zinc concentration following chronic but not acute zinc treatment in rats. Brain Res. 1090: 69-75.

Liguz-Lecznar M., Nowicka D., Czupryn A., Skangiel-Kramska J. (2005) Dissociation of synaptic zinc level and zinc transporter 3 expression during postnatal development and after sensory deprivation in the barrel cortex of mice. Brain Res. Bull. 66: 106-113

Czupryn A., Skangiel-Kramska J. (2003) Switch time-point for rapid experience-dependent changes in zinc-containing circuits in the mouse barrel cortex. Brain Res. Bull. 61: 385-391

Nowicka D., Liguz-Lecznar M., Skangiel-Kramska J. (2003) A surface antigen delineating a subset of neurons in the primary somatosensory cortex of the mouse. Acta Neurobiol. Exp. 63:185-195



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Published at: 2007-11-26 13:08
 

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