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nencki.gov.pl » Working Groups » Department of Molecular and Cellular Neurobiology »
Laboratory of Transport Through Biomembranes

Head
Katarzyna A. NAŁĘCZ

Staff
Magdalena CZEREDYS, Elżbieta JANUSZEWICZ, Natalia KULIKOVA, Maciej J. NALECZ, Łukasz SAMLUK, Karolina TUŁODZIECKA

Research profile

proteomics of transporters functioning in plasma membrane of various brain cells and transformed neural cells, with a special focus on carnitine, as well as studies on the role of palmitoylcarnitine on posttranslational modification of proteins, their interaction and cellular localization and implications of these effects on neuronal differentiation.

Current research activities

  • Studies on expression and characterization of carnitine transporters in the plasma membrane of neurons, astrocytes and brain capillary endothelial cells forming the blood-brain barrier;
  • Studies on regulation of transporters by phosphorylation;
  • Studies on involvement of palmitoylcarnitine in signal transduction and protein palmitoylation;

Selected publications

Miecz D., Januszewicz E., Czeredys M., Hinton B.T., Berezowski V., Cecchelli R.& Nałęcz K.A. (2008) Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier, J. Neurochem., 104, 113-123.

Czeredys M., Mysiorek C., Kulikova N., Samluk Ł., Berezowski V., Cecchelli R., Nałęcz K.A. (2008) A polarized localization of amino acid/carnitine transporter B0,+ (ATB0,+) in the blood-brain barrier, Biochem. Biophys. Res. Commun., 376, 267-270.

Miecz D., Januszewicz E., Czeredys M., Hinton B.T., Berezowski V., Cecchelli R. & Nałęcz K.A. (2007) Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier, J. Neurochem., 105: 113-123

Nałęcz K.A., Szczepankowska D., Czeredys M., Kulikova N. & Grześkiewicz S. (2007) palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP-43, FEBS Lett. 581, 3950-3954.

Sobiesiak-Mirska J. & Nałęcz K.A. (2006) Palmitoylcarnitine modulates interaction between protein kinase C bII and its receptor RACK1, FEBS J., 273, 1300-1311.



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Published at: 2009-07-28 11:46
 

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