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Department of Molecular and Cellular Neurobiology

Prof. Jolanta Skangiel-Kramska
e-mail: j.kramska@nencki.gov.pl

The Department of Molecular and Cellular Neurobiology is composed of eight independent laboratories headed by Professors: Anna Filipek, Leszek Kaczmarek, Małgorzata Kossut, Katarzyna Łukasiuk, Katarzyna Nałęcz, Krzysztof Pawłowski, Jolanta Skangiel-Kramska and Krzysztof Turlejski. Individual research programs in the laboratories are all complementary and interdependent within the common research area of molecular and cellular neurobiology

The group of Prof. Filipek studies the signal transduction processes leading to cell proliferation and differentiation via a calcium binding protein – S100A6 and its targets: Sgt1, CacyBP/SIP and p53. In particular, the laboratory is focused on studying the role of these proteins in ubiquitination, cytoskeleton rearrangement, cell response to stress factors as well as on studying the regulation of genes encoding S100A6, Sgt1 and CacyBP/SIP.

Prof. Kaczmarek and his colleagues study the molecular bases of persistent neuronal responses such as: neural plasticity, including learning and memory formation, and neurodegeneration bearing features of apoptosis. Transcription factors and their target genes are the major focus of this investigation.

The group of Prof. Łukasiuk works on molecular mechanisms of epileptogenesis and is interested in the role of alterations in gene expression leading to epilepsy and in designing new strategies for modifying disease development and severity. This laboratory is a member of Network of European Neuroscience Institutes ENI-NET.

The research of Prof. Małgorzata Kossut and her team is focused on visualization of systemic and neuronal mechanisms of  learning and plasticity in adult and ageing brain. The models of  plasticity developed in this laboratory serve to measure the effects of genetic modifications, brain disease and trauma upon functioning of the cerebral cortex.

Research in Prof. Nałęcz's laboratory is focused on differences in function and expression of various transport systems.  In particular, the expression of carnitine and amino acids in highly specialized brain cells, including those making the blood-brain barrier. Other research topics cover carnitine and palmitoylcarnitine and their role in signal transduction pathways in differentiating neural cells.

The laboratory of Dr Pawłowski works on structure and function predictions for proteins implicated in human disease, in particular uncharacterised transmembrane proteins. Another field of work is applying systems biology approaches to analysis of gene expression data and evolutionary analysis of gene expression profiles.

The laboratory of Prof. Skangiel-Kramska focuses on cortical plasticity during postnatal development and in the adult brain using neurochemical markers. The barrel cortex of rodents is used as a model system, and plastic changes are induced by modifications in sensory input patterns (sensory deprivation, sensory stimulation, and learning). Another area of focus is on the neuronal plasticity that occurs after cerebral stroke in the adult brain. Specific research concerns the study of neurotransmitter receptors, synaptic zinc and markers of presynaptic terminals and perineuronal nets.

Prof. Turlejski's group investigates the development of the nervous system in a laboratory opossum (Monodelphis domestica), division of its neocortex into various areas, and connection of these areas. Another research interest of the group is the comparative investigation of neurogenesis and its regulation in adult mammals (opposum, insectivores, rodents, carnivores, bats).

The Department holds weekly seminars and journal clubs. It is also actively involved in the organization of scientific symposia, meetings, workshops and research schools, including the schools of International Brain Research Organization (IBRO) and Federation of European Neuroscience Societies (FENS).

Members of our Department take on extensive additional responsibilities to serve the wider scientific community. These responsibilities include serving on a plethora of international and national committees and scientific societies. Prof. Leszek Kaczmarek is a member of the International Society for Neurochemistry (ISN), the Committee for Aid and Education in Neurochemistry and the European Molecular Biology Organization (EMBO) Fellowship Committee. He is a member of  the editorial boards of Acta Neurobiologiae Experimentalis, Onkologia Współczesna (deputy Editor-in-Chief), Psychologia-Etologia-Genetyka, Folia Morphologica (Warsz.), Folia Biologica (Praque), Neural Plasticity, Nonlinear Biomedical Physics, Neuropsychiatria i Neuropsychologia. Prof. Katarzyna Nałęcz is a member of the IBRO Nominating Committee and a member of the European Society for Neurochemistry (ESN) council. She is also a member of the editorial board of Journal of Neurochemistry. Prof. Jolanta Skangiel-Kramska is a President of Polish Neuroscience Society and a member of the editorial board of Acta Neurobiologiae Experimentalis. Prof. Małgorzata Kossut is a member of the executive council of European Dana Alliance for the Brain (EDAB). Dr. Izabela Figiel-Ożóg is a secretary for the Committee of Cytobiology at the Polish Academy of Sciences. Prof. Krzysztof Turlejski is the chair of a Local Commission on the Ethics of Animal Experimentation and is also a member of the IBRO Ethics Committee. He is also the Editor-in-Chief of the Acta Neurobiologiae Experimentalis, a scientific journal edited by the Polish Neuroscience Society.

Selected publications of the Department

Schneider G., Nieznanski K., Kilanczyk E., Bieganowski P., Kuznicki J., Filipek A. (2007) CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies Biochim.Biophys Acta – Mol. Cell Res. 1773: 1628-1636. 

Lesniak W., Slomnicki L.P., Kuznicki J. (2007) Epigenic Control of the S100A6 (Calcyclin) Gene Expression. J. Invest. Dermatol. 127:2307-2314.

Michaluk P., Kolodziej L., Mioduszewska B., Wilczynski G.M., Dzwonek J., Jaworski J., Gorecki D.C., Ottersen O.P., Kaczmarek L. (2007) β-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity. J. Biol. Chem., 282:16036-16041.

Okulski P., Jay T.M., Jaworski J., Duniec K., Dzwonek J., Konopacki F.A., Wilczynski G.M., Sánchez-Capeli A., Mallet J., Kaczmarek L. (2007) TIMP-1 abolishes MMP-9-dependent long-lasting LTP in the prefrontal cortex. Biol. Psych., 62: 359-362.

Knapska E., Radwanska K., Werka T., Kaczmarek L.(2007) Functional internal complexity of amygdala: focus on gene activity mapping following behavioral training and drugs of abuse. Physiol. Rev., 87: 1113-1173.

Tokarski K., Urban-Ciećko, Kossut M., Hess G. (2007) Sensory learning-induced enhancement of inhibitory synaptic transmission in the barrel cortex of the mouse. Eur.J. Neurosci. 26:132-144.

Kozlowska H., Jablonka J., Janowski M, Jurga M., Kossut M., Domanska-Janik K. (2007) Transplantation of human cord blood-derived neural-like stem cell line in a rat model of cortical infarct. Stem Cells Dev. 16:481-488.

Łukasiuk K., Pitkanen A. (2007) Gene and protein expression in experimental status epilepticus .  Epilepsia 48 (Suppl. 8): 28-32.

Liguz-Lecznar M., Skangiel-Kramska J.( 2007) Vesicular glutamate transporters VGLUT1 and VGLUT2 in the developing mouse barrel cortex. J. Devl. Neurosci. 25:107-114.

Djavadian R.L., Bisti S., Maccarone R., Bartkowska K.,Turlejski K. (2006) Development and plasticity of the retina in opossum Monodelphis domestica. Acta Neurobiol. Exp. 66:179-188

Siucińska E., Kossut M. (2006) Short-term sensory learning does not alter parvalbumin neurons in the barrel cortex of  adult mice: a double-labeling study. Neurosci. 138(2): 715-24

Miecz D., Januszewicz E., Czeredys M., Hinton B.T., Berezowski V., Cecchelli R., Nalecz K.A. (2007)Localization of organic cation? Carnitine transporter (OCTN2) in cell forming the blood-brain barrier. J. Neurochem. 103,doi: 10.1111/j.1471-4159.2007.05024.x

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Published at: 2007-11-26 13:12

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