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nencki.gov.pl » Working Groups » Department of Cell Biology »
Laboratory of Signal Transduction

Head
Tomasz WILANOWSKI

Staff
Michał MLĄCKI (PhD student)

Research profile

Signal transduction in mammalian cells; role of the Grainyhead-like (GRHL) transcription factors in this process; regulation of gene expression by the GRHL transcription factors; regulation of the activity of GRHL proteins; analysis of phenotypes of mouse strains carrying mutations in the Grhl genes; mechanisms of GRHL function in health and disease.

Current research activities

  • links between the GRHL1 gene and human disease

  • analysis of the phenotypes of Grhl1+/- and Grhl1-/- mice

  • mechanisms of regulation of the activity of GRHL1 protein

  • regulation of gene expression by the GRHL1 transcription factor

Selected publications

Wilanowski, T., Caddy, J., Ting, S. B., Hislop, N. R., Cerruti, L., Auden, A., Zhao, L.-L., Asquith, S., Ellis, S., Sinclair, R., Cunningham, J. M., Jane, S. M. (2008) Perturbed desmosomal cadherin expression in Grainy head-like 1-null mice. EMBO
J.
27: 886–897

Ting, S. B., Caddy, J., Hislop, N., Wilanowski, T., Auden, A., Zhao, L.-L., Ellis, S., Kaur, P., Uchida, Y., Holleran, W. M., Elias, P. M., Cunningham, J. M., Jane, S. M. (2005) A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science 308: 411-413

Ting, S. B., Wilanowski, T., Auden, A., Hall, M., Voss, A. K., Thomas, T., Parekh, V., Cunningham, J. M., Jane, S. M. (2003) Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat. Med. 9: 1513-1519

Ting, S. B., Wilanowski, T., Cerruti, L., Zhao, L.-L., Cunningham, J. M., Jane, S. M. (2003) The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. Biochem. J. 370: 953-962

Wilanowski, T., Tuckfield, A., Cerruti, L., O’Connell, S., Saint, R., Parekh, V., Tao, J., Cunningham, J. M., Jane, S. M. (2002)
A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech. Dev. 114: 37-50



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Published at: 2010-03-05 22:39
 

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