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Laboratory of Transcription Regulations
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nencki.gov.pl » Working Groups » Department of Cell Biology »
Laboratory of Transcription Regulation

Head
Bożena KAMIŃSKA-KACZMAREK

Staff
Iwona CIECHOMSKA, Michał DĄBROWSKI, Aleksandra ELLERT-MIKLASZEWSKA, Aleksandra WESOŁOWSKA, Małgorzata ZAWADZKA, Agata GÓŹDŹ (PolPostdoc II), Maciej LIPKO (PolPostdoc II), Alicja ADACH (PhD student), Konrad GABRUSIEWICZ (PhD student), Magdalena KLOCEK (PhD student),  Aneta KWIATKOWSKA (PhD student), Kinga SZYDŁOWSKA  (PhD student), Karolina ŚWIĄTEK-MACHADO (PhD student), Magdalena TYBURCZY (PhD student), Paweł WIŚNIEWSKI  (PhD student), Ahmed AHMED  (MD, Post-graduate School of Molecular Medicine), Beata KAZA (technician)

Research profile

Signalling cascades and gene expression associated with drug-induced apoptosis and autophagy of tumour cells; tumour-host interactions with focus on molecular mechanisms regulating tumour invasion and immunosuppression (laboratory is a member of Polish-French GDRE); targeting tumour growth using RNA interference and recombinant interfering peptide technology;  gene profiling and bioinformatics analysis of microarray and genomic data to identify gene regulatory underlying neurodegeneration and brain inflammation.

Current research activities

  • Characterising signalling pathways regulating survival and drug-induced glioma cell death in vitro and in vivo; focus on the role of AKT, mTOR, MAPK/AP-1 and JAK/STAT signalling in brain tumour survival, invasion, apoptosis and autophagy;
  • determining of microglia-glioma interactions in tumour pathology; role of tumour derived cytokines (FasL and TGFβ1) in the brain tumour pathology; application of siRNA interference and recombinant interfering peptide technology to affect tumour invasion, angiogenesis and tumour-related immunosuppression;
  • studies of molecular mechanisms of ischemia-induced inflammation and gliosis, effects of neuroprotectant FK506;
  • identification of gene expression profiles and cis-regulatory gene elements associated with patterns of expression underlying neurodegeneration and brain inflammation.

Selected publications

Wesolowska A, Kwiatkowska A, Slomnicki L, Dembiński M, Master M, Sliwa M, Franciszkiewicz K, Chouaib S, Kaminska B. (2007) Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. Oncogene, doi: 10.1038/sj.onc.1210683.

Sliwa M., Markovic D., Gabrusiewicz K., Synowitz M., Glass R., Zawadzka M., Wesolowska A., Kettenmann H., Kaminska B. (2007) The invasion promoting effect of microglia on glioblastoma cells is inhibited by cyclosporin A. BRAIN, 130:476-89.

Zupanska A., Adach A., Dziembowska M,, Kaminska B. (2007) Alternative pathway of transcriptional induction of p21WAF1/Cip1 by cyclosporine A in p53-deficient human glioblastoma cells. Cell Signal. 19:1268-1278.

Dabrowski M., Aerts S., Kaminska B. (2006) Prediction of a key role of motifs binding E2F and NR2F in down-regulation of numerous genes during the development of the mouse hippocampus. BMC Bioinformatics 7: 367-381.                                                                                           
Zawadzka M, Kaminska B (2005) A novel mechanism of FK506 mediated neuroprotection: down-regulation of cytokine expression in glial cells. Glia, 49: 36-51



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Published at: 2007-11-22 10:54
 

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